منابع مشابه
DNA adducts of chemical carcinogens.
Introduction During the 30 years or so following the identification of the first pure chemical carcinogen (1), no common factors or pathways in the mechanism of action of carcinogens from different chemical classes were evident. For this reason perhaps, each class of carcinogen, e.g. the polycyclic aromatic hydrocarbons, the aromatic amines and the nitrosamines, was often reviewed and discussed...
متن کاملCharacterization of covalent adriamycin-DNA adducts.
Adriamycin is a popular antineoplastic agent whose ability to form covalent adducts with DNA has been correlated to cellular apoptosis (programmed cell death) in tumor models. We have isolated and purified this adduct formed under oxido-reductive (Fenton) conditions in Tris buffer. We show by homo- and heteronuclear NMR spectroscopy that the covalent Adriamycin-DNA adduct is structurally equiva...
متن کاملRecognition of platinum-DNA adducts by HMGB1a.
Cisplatin (CP) and oxaliplatin (OX), platinum-based drugs used widely in chemotherapy, form adducts on intrastrand guanines (5'GG) in genomic DNA. DNA damage recognition proteins, transcription factors, mismatch repair proteins, and DNA polymerases discriminate between CP- and OX-GG DNA adducts, which could partly account for differences in the efficacy, toxicity, and mutagenicity of CP and OX....
متن کامل5 DNA Adducts and Their Consequences
1. the majority of carcinogens are also mutagens; 2. the mutagenic and carcinogenic properties of many carcinogens depend upon their conversion to electrophilic derivatives that react with nucleophilic sites within DNA; 3. the extent of DNA adduct formation can often be correlated with the magnitude of mutagenic and carcinogenic responses; and 4. the activation of certain proto-oncogenes can be...
متن کاملMonofunctional DNA-platinum(II) adducts block frequently DNA polymerases.
The question of whether monofunctional DNA platinum(II) adducts block synthesis of DNA by purified DNA polymerases of different types and origin has been investigated by comparing the time dependence of synthesis arrest and of DNA adduct formation. Activated salmon testis DNA is used as a suitable substrate for DNA synthesis allowing to probe inhibition by platinum(II) monoadducts for the varie...
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ژورنال
عنوان ژورنال: Biomedical and Pharmacology Journal
سال: 2015
ISSN: 0974-6242
DOI: 10.13005/bpj/660